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KMID : 0881720140290030248
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Journal of Food Hygiene and Safety
2014 Volume.29 No. 3 p.248 ~ p.251
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Effect of Methanol Extract of Dryopteris Crassirhizoma in Human Oral Cancer Cells
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Jang Boon-Sil
Oh Se-Jun
Shin Ji-Ae
Lee Hang-Eun
Cho Sung-Dae
Jeon Jae-Kyu
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Abstract
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Dryopteris crassirhizoma is one of the naturally occurring substance wood ferns and is known forhaving anti-inflammatory, antiviral and anthelmintic activities. However, there is less report about its anticancer effectin human cancer cell lines. In the present study, the effect of methanol extract of dryopteris crassirhizoma (MEDC) onapoptosis in human oral cancer cell lines (MC3 and HN22 cells) was investigated. MEDC inhibited cell viability andinduced apoptosis. MEDC significantly increased Bak and truncated Bid proteins in MC3 cells and elevated only truncatedBid compared to the control while other Bcl-2 family proteins were not altered. MEDC has anticancer activityby inducing apoptotic cell death through the regulation of either Bak or Bid. These findings suggest that its extractpossibly may be used for treating oral cancer.
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KEYWORD
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Dryopteris crassirhizoma, Apoptosis, Oral cancer, Bak, Bid
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